Norepinephrine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Norepinephrine biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOP9, TMED9, and H1-10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Norepinephrine biosynthetic process activity versus NOP9 in BREAST (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NOP9 →	-0.608	-1.124	.001	.001	3	4
BLOOD_Lymphoma	TMED9 →	+0.575	+1.093	.005	.005	3	3
BLOOD_Lymphoma	H1-10 →	+1.551	+1.360	.002	.002	2	4
BLOOD_Lymphoma	BCAP31 →	+0.856	+1.466	.003	<.001	3	3
BLOOD_Lymphoma	STX7 →	-1.806	-1.523	<.001	<.001	3	3
URINARY_TRACT	WFS1 →	+1.937	+0.452	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042421 vs NOP9 — BREAST

Explore this scatter interactively →