Norepinephrine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Norepinephrine biosynthetic process pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are IPA-3, AS605240, and Midostaurin, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IPA-3 grouped by Norepinephrine biosynthetic process-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IPA-3 →	-1.850	-2.106	.008	.003	3	1
LUNG_SCLC	AS605240 →	-1.114	-1.942	.044	.018	3	1
LUNG_SCLC	Midostaurin →	-1.244	-2.106	.049	.003	2	1
LUNG_SCLC	OSU-03012 →	-1.734	-2.106	.037	.003	2	1
LUNG_SCLC	TL-2-105 →	-0.764	-1.907	.011	.024	2	1
LUNG_SCLC	BX-912 →	-0.875	-1.645	.027	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IPA-3 by Norepinephrine biosynthetic process activity — LUNG_SCLC

Explore this box plot interactively →