Dopamine metabolic process

Across TCGA patient cohorts, RNA activity of the Dopamine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPO1, SF3B1, and SF3B6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopamine metabolic process activity versus XPO1 in LSCC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	XPO1 →	-0.271	-0.071	<.001	<.001	3	7
GBM	SF3B1 →	-0.258	-0.056	<.001	<.001	3	7
GBM	SF3B6 →	-0.281	-0.048	<.001	<.001	3	7
LSCC	SIAE →	+0.388	+0.060	<.001	<.001	3	7
GBM	U2SURP →	-0.345	-0.083	<.001	<.001	3	7
GBM	CHERP →	-0.245	-0.047	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042417 vs XPO1 — LSCC

Explore this scatter interactively →