Dopamine metabolic process

Across TCGA cell cohorts, RNA activity of the Dopamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA3, POLN, and TRMT10B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ANXA3 grouped by Dopamine metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ANXA3 →	-3.493	-1.408	.006	<.001	3	3
OESOPHAGUS	POLN →	+0.613	+0.316	.002	<.001	3	3
LUNG_SCLC	TRMT10B →	-0.800	-0.507	<.001	.008	3	3
BLOOD_Leukemia	MDM2 →	+1.543	+0.246	.003	.003	3	3
OVARY	NARS1 →	+0.618	+0.587	.006	.003	3	3
BONE	COX14 →	+0.577	+0.312	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ANXA3 by Dopamine metabolic process activity — LIVER

Explore this box plot interactively →