Dopamine metabolic process

Across TCGA cell cohorts, RNA activity of the Dopamine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS27A, ALDH2, and LAMA4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopamine metabolic process activity versus RPS27A in URINARY_TRACT (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RPS27A →	+0.872	+0.410	<.001	<.001	3	4
BREAST	ALDH2 →	+3.017	+0.515	.001	.003	3	4
URINARY_TRACT	LAMA4 →	-4.066	-0.395	<.001	.009	3	3
URINARY_TRACT	CERS5 →	-0.595	-0.410	<.001	<.001	3	3
URINARY_TRACT	PXYLP1 →	+1.449	+0.454	.006	<.001	3	3
URINARY_TRACT	PTRHD1 →	+0.731	+0.356	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042417 vs RPS27A — URINARY_TRACT

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