Dopamine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Dopamine biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KIF11_T926, TTC27, and TBC1D9_S471, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopamine biosynthetic process activity versus KIF11_T926 in BRCA (Pearson r = -0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIF11_T926 →	-0.735	-0.050	<.001	.004	3	6
HNSC	TTC27 →	-0.364	-0.094	<.001	<.001	3	5
GBM	TBC1D9_S471 →	+0.593	+0.141	<.001	<.001	3	5
LSCC	DNAJC1 →	+0.466	+0.088	<.001	.001	3	5
HNSC	ABCE1 →	-0.193	-0.074	.001	.001	3	5
LSCC	HSD17B11 →	+0.317	+0.063	.007	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042416 vs KIF11_T926 — BRCA

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