Dopamine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Dopamine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HBB, ITIH5, and ITGA8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopamine biosynthetic process activity versus HBB in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HBB →	+1.653	+0.130	<.001	<.001	3	5
LSCC	ITIH5 →	+0.776	+0.114	<.001	<.001	3	4
COAD	ITGA8 →	+0.415	+0.125	.001	.004	3	4
PDAC	DMD →	+0.441	+0.069	.003	.007	3	4
CCRCC	PGM5P4 →	+0.835	+0.104	<.001	.002	3	4
HNSC	NTRK2 →	+1.532	+0.134	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042416 vs HBB — BRCA

Explore this scatter interactively →