Dopamine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Dopamine biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TVP23A, CCNDBP1, and GABRD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TVP23A grouped by Dopamine biosynthetic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TVP23A →	-0.136	-1.733	.005	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CCNDBP1 →	-0.170	-0.146	.007	.003	3	3
UPPER_AERODIGESTIVE_TRACT	GABRD →	-0.096	-0.210	<.001	<.001	3	3
LUNG_SCLC	NEGR1 →	+0.228	+0.869	<.001	.004	3	3
BLOOD_Myeloma	JAK2 →	-0.297	-1.792	.003	<.001	3	3
BLOOD_Leukemia	KDM4C →	+0.203	+1.286	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TVP23A by Dopamine biosynthetic process activity — PANCREAS

Explore this box plot interactively →