Dopamine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Dopamine biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTARC1, UBE2H, and WNT7B, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTARC1 grouped by Dopamine biosynthetic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MTARC1 →	+0.105	+2.054	.002	.001	2	1
LUNG_SCLC	UBE2H →	+0.279	+2.054	.007	.001	2	1
LUNG_SCLC	WNT7B →	+0.273	+2.054	.008	.001	2	1
LUNG_SCLC	BLOC1S2 →	+0.230	+2.164	.008	.003	2	1
LUNG_SCLC	CAPZA2 →	+0.248	+2.054	.007	.001	2	1
LUNG_SCLC	HSD3BP4 →	+0.141	+2.054	.001	.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTARC1 by Dopamine biosynthetic process activity — LUNG_SCLC

Explore this box plot interactively →