Norepinephrine metabolic process

Across TCGA patient cohorts, RNA activity of the Norepinephrine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HEATR1, SEPTIN4, and SHROOM4_S299, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Norepinephrine metabolic process activity versus HEATR1 in LSCC (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HEATR1 →	-0.316	-0.072	<.001	<.001	3	8
PDAC	SEPTIN4 →	+0.552	+0.091	<.001	<.001	3	7
CCRCC	SHROOM4_S299 →	+0.595	+0.088	<.001	.001	3	7
CCRCC	SORBS1 →	+0.648	+0.106	<.001	<.001	3	7
CCRCC	VCL_Y822 →	+0.399	+0.077	<.001	<.001	3	7
CCRCC	C1orf198_S175 →	+1.014	+0.147	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042415 vs HEATR1 — LSCC

Explore this scatter interactively →