Norepinephrine metabolic process

Across TCGA cell cohorts, RNA activity of the Norepinephrine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P2RX2, MIR1915HG, and STX11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, P2RX2 grouped by Norepinephrine metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	P2RX2 →	+0.048	+0.385	<.001	.008	3	4
CNS	MIR1915HG →	+0.828	+0.585	.001	.005	3	4
SOFT_TISSUE	STX11 →	+2.565	+1.189	.001	<.001	3	3
BLOOD_Myeloma	H4-16 →	+0.973	+1.362	.004	.003	3	3
SOFT_TISSUE	ZMAT2 →	+0.570	+0.921	.003	.002	3	3
SOFT_TISSUE	HACD2 →	-0.629	-0.947	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P2RX2 by Norepinephrine metabolic process activity — CNS

Explore this box plot interactively →