Norepinephrine metabolic process

Across TCGA cell cohorts, RNA activity of the Norepinephrine metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYAR, AMMECR1, and SLC38A1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LYAR grouped by Norepinephrine metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LYAR →	+0.121	+1.416	.002	<.001	3	2
BREAST	AMMECR1 →	-0.696	-1.926	.001	<.001	3	1
BREAST	SLC38A1 →	+0.181	+1.416	.002	<.001	3	1
BREAST	UTP18 →	-0.329	-1.232	<.001	.006	3	1
BREAST	XRN1 →	-0.262	-1.432	.001	.009	2	2
BREAST	MYOT →	+0.133	+1.256	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LYAR by Norepinephrine metabolic process activity — BREAST

Explore this box plot interactively →