Norepinephrine metabolic process

Across TCGA cell cohorts, RNA activity of the Norepinephrine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LYPD8, INTS6, and NME4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Norepinephrine metabolic process activity versus LYPD8 in BREAST (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LYPD8 →	+0.539	+1.250	<.001	.006	3	2
BREAST	INTS6 →	+0.970	+1.250	.004	.006	3	1
BREAST	NME4 →	+1.131	+1.250	.004	.006	3	1
BREAST	ABCA2 →	+1.744	+1.250	.005	.006	3	1
BREAST	UTP6 →	+1.033	+1.918	.005	<.001	3	1
BREAST	EIF2B1 →	+0.509	+1.250	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042415 vs LYPD8 — BREAST

Explore this scatter interactively →