Cristae formation

Across TCGA patient cohorts, RNA activity of the Cristae formation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R18, RPL22L1, and EHBP1L1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cristae formation activity versus PPP1R18 in LUAD (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PPP1R18 →	-0.288	-0.022	<.001	.004	3	6
GBM	RPL22L1 →	-0.672	-0.031	.002	.001	3	5
GBM	EHBP1L1 →	-0.481	-0.034	<.001	<.001	3	5
LUAD	PLCG2 →	-0.332	-0.031	<.001	<.001	3	5
BRCA	LZIC →	+0.432	+0.036	<.001	<.001	3	5
GBM	TNFAIP3 →	-0.341	-0.031	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042407 vs PPP1R18 — LUAD

Explore this scatter interactively →