Cristae formation

Across TCGA patient cohorts, RNA activity of the Cristae formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS7P11, MTCO1P12, and MTCO1P40, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cristae formation activity versus RPS7P11 in BRCA (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPS7P11 →	+1.036	+0.182	.002	<.001	3	4
BRCA	MTCO1P12 →	+0.729	+0.113	.005	.009	3	4
BRCA	MTCO1P40 →	+1.230	+0.156	<.001	<.001	3	4
GBM	BEX2 →	+0.809	+0.119	.002	.001	3	4
GBM	FES →	-0.341	-0.095	.008	<.001	3	4
GBM	DBIP1 →	+0.623	+0.084	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042407 vs RPS7P11 — BRCA

Explore this scatter interactively →