Cristae formation

Across TCGA patient cohorts, RNA activity of the Cristae formation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UQCRFS1, VDAC2, and SCO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cristae formation activity versus UQCRFS1 in BRCA (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UQCRFS1 →	+0.436	+0.223	<.001	<.001	3	4
PDAC	VDAC2 →	+0.555	+0.250	<.001	<.001	3	4
BRCA	SCO1 →	+0.339	+0.147	<.001	<.001	3	4
GBM	SFXN1 →	+0.403	+0.178	<.001	<.001	3	4
PDAC	ATP5MD →	+0.582	+0.189	<.001	<.001	3	4
UCEC	VDAC1 →	+0.407	+0.265	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042407 vs UQCRFS1 — BRCA

Explore this scatter interactively →