Cristae formation

Across TCGA cell cohorts, RNA activity of the Cristae formation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNHIT3, CBX4, and SMYD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNHIT3 grouped by Cristae formation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNHIT3 →	+0.338	+0.318	.006	.008	3	3
BREAST	CBX4 →	+1.165	+0.500	.001	.002	3	3
BREAST	SMYD2 →	+1.040	+0.356	<.001	<.001	3	3
BREAST	CHDH →	+1.234	+0.337	.001	.009	3	3
BREAST	ZNF138 →	+0.714	+0.364	.001	.006	3	3
BONE	CALHM1 →	+0.036	+0.392	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNHIT3 by Cristae formation activity — STOMACH

Explore this box plot interactively →