Cristae formation

Across TCGA cell cohorts, RNA activity of the Cristae formation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBQLN2, BMP7, and MZT2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cristae formation activity versus UBQLN2 in OESOPHAGUS (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	UBQLN2 →	+0.967	+0.272	<.001	.001	3	4
OVARY	BMP7 →	+3.770	+0.276	<.001	.001	3	4
OVARY	MZT2A →	-0.552	-0.205	.009	.003	3	4
CNS	HCCS →	+1.055	+0.298	<.001	<.001	3	4
LUNG_SCLC	SPEF1 →	+0.341	+0.155	.005	.003	3	4
LUNG_SCLC	AOPEP →	+1.186	+0.175	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042407 vs UBQLN2 — OESOPHAGUS

Explore this scatter interactively →