Thyroid hormone metabolic process

Across TCGA patient cohorts, RNA activity of the Thyroid hormone metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GLTP, RAB14, and COBLL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thyroid hormone metabolic process activity versus GLTP in HNSC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GLTP →	+0.457	+0.049	<.001	<.001	3	5
BRCA	RAB14 →	+0.219	+0.038	.003	.002	3	5
PDAC	COBLL1 →	+0.245	+0.055	.001	<.001	3	5
LUAD	HDAC2 →	-0.264	-0.060	<.001	.001	3	5
BRCA	TMEM134 →	+0.449	+0.059	.001	<.001	3	4
LSCC	BRMS1L_S197 →	-0.372	-0.041	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042403 vs GLTP — HNSC

Explore this scatter interactively →