Thyroid hormone metabolic process

Across TCGA cell cohorts, RNA activity of the Thyroid hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P3H1, DNAJB9, and POFUT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, P3H1 grouped by Thyroid hormone metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	P3H1 →	-0.885	-0.717	.002	.001	3	4
CNS	DNAJB9 →	-0.808	-0.889	.003	.001	3	4
CNS	POFUT2 →	-0.923	-0.912	.004	<.001	3	4
URINARY_TRACT	YPEL5 →	-1.570	-1.503	.004	.009	3	4
URINARY_TRACT	PMEL →	-1.003	-1.295	.004	.005	3	4
UPPER_AERODIGESTIVE_TRACT	TMEM132A →	-1.803	-1.504	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P3H1 by Thyroid hormone metabolic process activity — CNS

Explore this box plot interactively →