Thyroid hormone metabolic process

Across TCGA cell cohorts, RNA activity of the Thyroid hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHJ1, HLA-DMA, and REXO5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thyroid hormone metabolic process activity versus PLEKHJ1 in LUNG_SCLC (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLEKHJ1 →	-1.195	-1.653	.001	<.001	3	3
LUNG_SCLC	HLA-DMA →	+2.242	+1.753	.001	<.001	3	3
LUNG_SCLC	REXO5 →	-1.262	-1.343	.007	.009	3	3
LIVER	FANCB →	+1.210	+0.490	.005	.003	3	3
CNS	P2RX7 →	+1.134	+0.168	.007	.007	1	5
OVARY	PPP1R15A →	+2.592	+0.195	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042403 vs PLEKHJ1 — LUNG_SCLC

Explore this scatter interactively →