Vitamin K metabolic process

Across TCGA patient cohorts, RNA activity of the Vitamin K metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP4F11, SMIM10L2A, and EPHX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin K metabolic process activity versus CYP4F11 in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CYP4F11 →	+1.689	+0.138	.003	<.001	3	4
BRCA	SMIM10L2A →	+0.729	+0.186	.002	.002	3	4
HNSC	EPHX1 →	+0.791	+0.147	<.001	<.001	3	4
HNSC	CYP4F3 →	+1.516	+0.180	<.001	<.001	3	4
LUAD	TXNDC11 →	+0.397	+0.134	.002	.002	3	3
GBM	LDHD →	+0.488	+0.181	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042373 vs CYP4F11 — LSCC

Explore this scatter interactively →