Vitamin K metabolic process

Across TCGA cell cohorts, RNA activity of the Vitamin K metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP4F2, GGCX, and CYP4F11, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP4F2 grouped by Vitamin K metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CYP4F2 →	-0.317	-1.238	<.001	<.001	3	11
STOMACH	GGCX →	-0.489	-1.576	.006	.002	2	11
KIDNEY	CYP4F11 →	-0.216	-1.481	.007	<.001	3	8
SKIN	VKORC1L1 →	-0.248	-1.504	.001	<.001	3	6
BLOOD_Myeloma	AIG1 →	-0.386	-2.013	.003	<.001	3	5
LUNG_NSCLC_LUAD	PPFIA1 →	+0.202	+1.059	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP4F2 by Vitamin K metabolic process activity — CNS

Explore this box plot interactively →