Vitamin K metabolic process

Across TCGA cell cohorts, RNA activity of the Vitamin K metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBR1, AKR1C1, and LIPG, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin K metabolic process activity versus CBR1 in LUNG_SCLC (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CBR1 →	+2.460	+0.912	.007	.008	3	9
LUNG_NSCLC_LUAD	AKR1C1 →	+3.534	+0.578	<.001	<.001	3	8
URINARY_TRACT	LIPG →	-5.015	-2.360	<.001	.007	3	6
STOMACH	CHKA →	-1.211	-1.397	.003	.005	3	5
STOMACH	PHLDB2 →	-2.842	-1.014	.002	.004	3	5
URINARY_TRACT	ACBD5 →	+1.032	+2.031	.003	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042373 vs CBR1 — LUNG_SCLC

Explore this scatter interactively →