Fat-soluble vitamin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Fat-soluble vitamin biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SASH3, SKAP2, and THEMIS2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fat-soluble vitamin biosynthetic process activity versus SASH3 in GBM (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SASH3 →	+0.480	+0.078	<.001	<.001	3	9
GBM	SKAP2 →	+0.748	+0.086	<.001	<.001	3	9
UCEC	THEMIS2 →	+0.623	+0.080	<.001	<.001	3	9
GBM	THEMIS2_T593 →	+0.668	+0.082	<.001	<.001	3	9
GBM	VAV1 →	+0.626	+0.084	<.001	<.001	3	9
GBM	WAS →	+0.570	+0.068	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042362 vs SASH3 — GBM

Explore this scatter interactively →