Fat-soluble vitamin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Fat-soluble vitamin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MINDY1, MDM2, and FCSK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MINDY1 grouped by Fat-soluble vitamin biosynthetic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MINDY1 →	-0.585	-0.832	.009	.002	3	5
LIVER	MDM2 →	-1.496	-1.323	<.001	.003	2	5
BREAST	FCSK →	-0.715	-0.755	.009	.007	2	5
LUNG_SCLC	SLC44A3 →	-2.565	-1.219	<.001	.006	2	5
STOMACH	TATDN1 →	+0.985	+1.258	.003	<.001	3	4
LUNG_NSCLC_LUAD	SCP2 →	-0.595	-0.883	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MINDY1 by Fat-soluble vitamin biosynthetic process activity — SKIN

Explore this box plot interactively →