Fat-soluble vitamin biosynthetic process

Across TCGA cell cohorts, RNA activity of the Fat-soluble vitamin biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PROKR1, IL17RB, and SLC9A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PROKR1 grouped by Fat-soluble vitamin biosynthetic process-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PROKR1 →	-0.290	-0.184	<.001	.007	3	4
LIVER	IL17RB →	+0.245	+0.101	.002	.005	3	4
PANCREAS	SLC9A1 →	-0.181	-1.032	<.001	.002	3	3
SOFT_TISSUE	RGR →	-0.209	-0.789	<.001	.005	3	3
OESOPHAGUS	ELAVL2 →	+0.128	+1.167	.007	.001	3	3
OESOPHAGUS	ITGAV →	+0.201	+1.247	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PROKR1 by Fat-soluble vitamin biosynthetic process activity — BLOOD_Myeloma

Explore this box plot interactively →