Vitamin E metabolic process

Across TCGA patient cohorts, RNA activity of the Vitamin E metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PITRM1, RFX3, and HTATIP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin E metabolic process activity versus PITRM1 in GBM (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PITRM1 →	+0.286	+0.121	.001	.007	3	6
GBM	RFX3 →	-0.372	-0.134	.001	<.001	3	5
GBM	HTATIP2 →	+0.539	+0.127	<.001	<.001	3	5
LSCC	PNISR →	-0.213	-0.142	.005	<.001	3	5
PDAC	KIFC3 →	+0.420	+0.113	.001	<.001	3	5
GBM	GABPA →	-0.291	-0.141	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042360 vs PITRM1 — GBM

Explore this scatter interactively →