Vitamin D metabolic process

Across TCGA cell cohorts, RNA activity of the Vitamin D metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACAA2, GSTA4, and KLF13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACAA2 grouped by Vitamin D metabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACAA2 →	-1.517	-0.916	.006	.002	3	5
LUNG_NSCLC_LUAD	GSTA4 →	-2.457	-1.080	<.001	<.001	3	5
LUNG_SCLC	KLF13 →	-1.304	-1.062	<.001	.009	3	5
LUNG_SCLC	IGF2BP2 →	+3.938	+1.373	<.001	.001	3	5
LUNG_NSCLC_LUAD	MT1E →	+4.483	+0.837	<.001	.003	3	4
STOMACH	TOX2 →	+2.520	+1.044	.009	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACAA2 by Vitamin D metabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →