Thiamine diphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Thiamine diphosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BTK, HDDC3, and ANKRD44, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thiamine diphosphate metabolic process activity versus BTK in UCEC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BTK →	+0.342	+0.075	.006	.002	3	5
UCEC	HDDC3 →	+0.365	+0.076	<.001	.001	3	5
UCEC	ANKRD44 →	+0.328	+0.064	.001	.006	3	5
PDAC	LAMB3 →	-0.768	-0.062	<.001	<.001	3	4
CCRCC	BLNK →	+0.266	+0.053	.001	.002	2	5
CCRCC	DENND5B_S1076 →	+0.309	+0.036	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042357 vs BTK — UCEC

Explore this scatter interactively →