Thiamine diphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Thiamine diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD37, LPXN, and TRBC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thiamine diphosphate metabolic process activity versus CD37 in LSCC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CD37 →	+0.606	+0.487	<.001	<.001	3	5
LSCC	LPXN →	+0.528	+0.825	<.001	<.001	3	5
LSCC	TRBC2 →	+0.735	+0.811	.002	<.001	3	5
LUAD	ADGRE5 →	+0.508	+0.196	.004	.002	3	4
LSCC	IGSF6 →	+0.471	+0.476	<.001	<.001	3	4
LUAD	GPR25 →	+0.362	+0.179	.008	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042357 vs CD37 — LSCC

Explore this scatter interactively →