Thiamine diphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Thiamine diphosphate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBR4, POLH, and DDOST, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CBR4 grouped by Thiamine diphosphate metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CBR4 →	-0.248	-1.606	.001	<.001	3	3
OESOPHAGUS	POLH →	-0.173	-1.320	.001	.001	3	3
OESOPHAGUS	DDOST →	-0.279	-1.196	<.001	.001	3	3
STOMACH	FERMT2 →	-0.211	-0.113	.002	.005	3	3
CNS	PLOD2 →	+0.261	+0.733	<.001	.005	3	3
LARGE_INTESTINE	FIGNL2 →	+0.101	+0.095	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CBR4 by Thiamine diphosphate metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →