Keratan sulfate metabolic process

Across TCGA patient cohorts, RNA activity of the Keratan sulfate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AFF4_S680, POGZ, and CTR9_S1085, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratan sulfate metabolic process activity versus AFF4_S680 in OV (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AFF4_S680 →	-0.711	-0.086	.002	<.001	3	6
GBM	POGZ →	-0.276	-0.077	<.001	<.001	3	6
LSCC	CTR9_S1085 →	-0.389	-0.053	.002	<.001	3	6
GBM	RSRC2_S105 →	-0.504	-0.070	<.001	<.001	3	5
UCEC	SLC16A1 →	-0.759	-0.053	.003	.006	3	5
BRCA	ARPC5 →	+0.242	+0.028	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042339 vs AFF4_S680 — OV

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