Keratan sulfate metabolic process

Across TCGA patient cohorts, RNA activity of the Keratan sulfate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VDAC2P2, KLRG1, and IL20RA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratan sulfate metabolic process activity versus VDAC2P2 in LSCC (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VDAC2P2 →	-0.431	-0.153	.001	.005	3	4
LUAD	KLRG1 →	-0.557	-0.217	.002	.005	3	3
HNSC	IL20RA →	+0.507	+0.172	.006	.006	3	3
LSCC	SLC22A3 →	-0.716	-0.182	.003	.003	3	3
LSCC	GPR174 →	-0.707	-0.188	<.001	<.001	2	4
LSCC	TRAV26-1 →	-0.630	-0.279	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042339 vs VDAC2P2 — LSCC

Explore this scatter interactively →