Keratan sulfate metabolic process

Across TCGA cell cohorts, RNA activity of the Keratan sulfate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN2, ATP7B, and RETREG1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEPTIN2 grouped by Keratan sulfate metabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SEPTIN2 →	+0.958	+0.974	.002	.004	3	6
BLOOD_Myeloma	ATP7B →	+0.964	+1.576	.007	<.001	3	5
BLOOD_Myeloma	RETREG1 →	-0.637	-1.512	.006	.003	3	5
STOMACH	WDR75 →	+0.983	+0.953	<.001	.002	3	5
CNS	SATB2 →	+0.521	+0.922	.005	.004	3	4
CNS	OR4F17 →	+0.137	+1.164	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEPTIN2 by Keratan sulfate metabolic process activity — OESOPHAGUS

Explore this box plot interactively →