Keratan sulfate metabolic process

Across TCGA cell cohorts, RNA activity of the Keratan sulfate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLB1, LPP, and TBCK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Keratan sulfate metabolic process activity versus GLB1 in URINARY_TRACT (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GLB1 →	+0.697	+0.424	.007	.004	2	5
SKIN	LPP →	+0.499	+0.479	.003	.001	3	3
SKIN	TBCK →	+0.589	+0.240	.003	.008	3	3
STOMACH	MRPL2 →	-0.815	-1.431	<.001	.002	3	3
LUNG_NSCLC_LUAD	DENND5A →	+0.646	+0.425	.005	.004	3	3
LUNG_NSCLC_LUAD	STRADB →	+0.872	+0.433	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042339 vs GLB1 — URINARY_TRACT

Explore this scatter interactively →