Negative regulation of protein import into nucleus

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein import into nucleus pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YY2, SETDB2, and MRPS33, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein import into nucleus activity versus YY2 in SKIN (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	YY2 →	+0.846	+0.250	.007	.007	3	5
LUNG_NSCLC_LUAD	SETDB2 →	+0.388	+0.136	<.001	.006	3	5
BLOOD_Lymphoma	MRPS33 →	+0.788	+0.151	.004	.007	3	5
BLOOD_Lymphoma	PTPN3 →	-1.924	-0.159	.008	.008	3	4
BLOOD_Myeloma	TGDS →	+0.822	+0.333	.003	.001	3	4
OESOPHAGUS	CMTM2 →	-0.254	-0.159	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042308 vs YY2 — SKIN

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