Positive regulation of protein import into nucleus

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein import into nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCN3, SPARC, and SULF1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein import into nucleus activity versus RCN3 in LSCC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCN3 →	+0.847	+0.240	.001	<.001	3	9
LSCC	SPARC →	+0.757	+0.146	<.001	<.001	3	8
CCRCC	SULF1 →	+1.075	+0.230	<.001	<.001	3	8
LUAD	GREM1 →	+1.181	+0.184	.001	.001	3	8
CCRCC	THBS2 →	+1.285	+0.180	<.001	<.001	3	8
LSCC	COL5A2 →	+1.247	+0.294	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042307 vs RCN3 — LSCC

Explore this scatter interactively →