Positive regulation of protein import into nucleus

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein import into nucleus pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED13, SMG8, and MED24, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED13 grouped by Positive regulation of protein import into nucleus-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MED13 →	+0.621	+0.120	.002	.001	3	4
OESOPHAGUS	SMG8 →	+0.577	+0.111	<.001	.001	3	4
LUNG_SCLC	MED24 →	+0.745	+0.240	<.001	<.001	3	4
OVARY	NPC2 →	-1.485	-0.253	.004	<.001	3	4
KIDNEY	CHD2 →	+0.688	+0.178	.001	.008	3	4
PANCREAS	PCGF1 →	+0.658	+0.174	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED13 by Positive regulation of protein import into nucleus activity — OESOPHAGUS

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