Positive regulation of protein import into nucleus

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein import into nucleus pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEK1, HCFC1, and UNC13D, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein import into nucleus activity versus NEK1 in URINARY_TRACT (Pearson r = -0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NEK1 →	-0.925	-0.358	.009	.002	3	7
OESOPHAGUS	HCFC1 →	+0.664	+0.221	.001	<.001	2	7
STOMACH	UNC13D →	+3.812	+0.285	.001	.004	3	5
BLOOD_Myeloma	MKI67 →	+1.918	+0.208	.007	.002	3	5
BLOOD_Leukemia	ARHGAP19 →	+0.810	+0.184	.003	.002	3	5
OVARY	GBE1 →	-1.486	-0.213	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042307 vs NEK1 — URINARY_TRACT

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