Regulation of protein import into nucleus

Across TCGA cell cohorts, RNA activity of the Regulation of protein import into nucleus pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERICH6B, LSM1, and FKBP10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERICH6B grouped by Regulation of protein import into nucleus-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ERICH6B →	+0.241	+0.106	.003	.004	3	4
UPPER_AERODIGESTIVE_TRACT	LSM1 →	-0.753	-0.171	.006	.004	3	4
BREAST	FKBP10 →	-2.308	-0.121	.006	.001	3	3
LUNG_NSCLC_LUSC	REC8 →	+1.300	+0.233	.006	.001	3	3
OESOPHAGUS	FERMT3 →	+1.023	+0.150	.006	<.001	3	3
OESOPHAGUS	CXXC5 →	-2.331	-0.163	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERICH6B by Regulation of protein import into nucleus activity — SKIN

Explore this box plot interactively →