Regulation of protein import into nucleus

Across TCGA cell cohorts, RNA activity of the Regulation of protein import into nucleus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MECP2, RTEL1, and DTNB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein import into nucleus activity versus MECP2 in BLOOD_Leukemia (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MECP2 →	+0.624	+0.214	.002	.001	3	5
OESOPHAGUS	RTEL1 →	+1.172	+0.167	<.001	<.001	3	5
LARGE_INTESTINE	DTNB →	+1.334	+0.176	<.001	<.001	3	4
BLOOD_Myeloma	STOM →	-2.749	-0.187	.006	.001	3	4
BLOOD_Leukemia	OAF →	-1.640	-0.161	.001	.002	3	4
BLOOD_Leukemia	GNL1 →	+0.842	+0.188	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042306 vs MECP2 — BLOOD_Leukemia

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