Regulation of fatty acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of fatty acid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SDS, AMPD3, and SRRM2_S1424, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fatty acid biosynthetic process activity versus SDS in LSCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SDS →	+0.612	+0.053	<.001	<.001	3	6
GBM	AMPD3 →	+0.324	+0.030	.009	.005	3	6
BRCA	SRRM2_S1424 →	-0.615	-0.035	.004	<.001	3	5
GBM	TOP2B_S1552 →	-0.439	-0.058	.003	<.001	3	5
GBM	LILRB2 →	+0.993	+0.083	.003	.001	3	5
GBM	PIK3AP1 →	+0.495	+0.042	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042304 vs SDS — LSCC

Explore this scatter interactively →