Regulation of fatty acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V1C1, MX2, and LCN12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP6V1C1 grouped by Regulation of fatty acid biosynthetic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ATP6V1C1 →	-1.091	-0.368	.004	.001	3	4
BLOOD_Lymphoma	MX2 →	-5.222	-0.435	.001	.001	3	4
BLOOD_Lymphoma	LCN12 →	+0.604	+0.397	<.001	<.001	3	4
BREAST	NUDT17 →	+0.652	+0.276	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SRPX2 →	-2.788	-0.474	<.001	.002	3	3
LUNG_NSCLC_LUAD	HELZ2 →	-0.885	-0.363	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP6V1C1 by Regulation of fatty acid biosynthetic process activity — BLOOD_Lymphoma

Explore this box plot interactively →