Regulation of fatty acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD14B, TANGO6, and BLCAP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of fatty acid biosynthetic process activity versus ABHD14B in BREAST (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ABHD14B →	+0.952	+0.221	<.001	.004	3	6
OVARY	TANGO6 →	+1.022	+0.232	.003	.008	3	6
LIVER	BLCAP →	-1.065	-0.337	.002	.005	3	6
STOMACH	CPVL →	-3.358	-0.180	<.001	.009	2	6
OVARY	GRHL1 →	-1.243	-0.294	.002	.002	3	5
LARGE_INTESTINE	PIGT →	-0.760	-0.286	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042304 vs ABHD14B — BREAST

Explore this scatter interactively →