Molting cycle

Across TCGA patient cohorts, RNA activity of the Molting cycle pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP15, KLHL6, and FLT3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Molting cycle activity versus ARHGAP15 in LSCC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARHGAP15 →	-1.044	-0.436	<.001	.001	3	5
UCEC	KLHL6 →	-1.169	-1.236	<.001	<.001	3	5
LSCC	FLT3 →	-0.683	-0.346	<.001	.001	3	5
GBM	BIN1 →	-0.528	-0.335	<.001	<.001	3	5
LSCC	IRF8 →	-1.209	-0.454	<.001	<.001	3	5
GBM	CORO7 →	-0.318	-0.317	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042303 vs ARHGAP15 — LSCC

Explore this scatter interactively →