Molting cycle

Across TCGA cell cohorts, RNA activity of the Molting cycle pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB11FIP5, SLC29A3, and SYTL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB11FIP5 grouped by Molting cycle-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RAB11FIP5 →	-1.181	-0.912	.002	.002	3	4
LIVER	SLC29A3 →	+2.303	+1.958	.005	<.001	3	4
CNS	SYTL3 →	-1.171	-0.817	.003	.006	3	4
CNS	CD163L1 →	-2.154	-0.995	<.001	<.001	3	4
LUNG_SCLC	CFAP20DC →	-1.789	-1.115	.006	.001	3	4
LUNG_NSCLC_LUAD	RHOV →	+1.864	+0.639	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB11FIP5 by Molting cycle activity — CNS

Explore this box plot interactively →