Molting cycle

Across TCGA cell cohorts, RNA activity of the Molting cycle pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORO7-PAM16, TRIM37, and CTSD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CORO7-PAM16 grouped by Molting cycle-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CORO7-PAM16 →	-0.156	-0.194	.001	.005	3	5
KIDNEY	TRIM37 →	+0.234	+0.132	.006	.009	3	4
LUNG_SCLC	CTSD →	+0.140	+0.131	.001	.003	3	4
PANCREAS	SLC25A18 →	+0.149	+0.127	.003	.006	3	4
PANCREAS	HSD17B11 →	-0.195	-0.164	<.001	.001	3	4
BLOOD_Myeloma	ABCA2 →	-0.210	-0.231	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CORO7-PAM16 by Molting cycle activity — BREAST

Explore this box plot interactively →