Purine nucleoside metabolic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MFSD10, DCAF1, and FRMD4A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside metabolic process activity versus MFSD10 in HNSC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MFSD10 →	-0.279	-0.048	<.001	.005	3	5
GBM	DCAF1 →	-0.200	-0.048	.004	.001	3	4
PDAC	FRMD4A →	+0.337	+0.047	<.001	<.001	3	4
HNSC	ANXA2_S164 →	-0.380	-0.062	<.001	<.001	3	4
HNSC	NSUN5 →	+0.167	+0.044	.002	<.001	3	4
COAD	INPP1 →	+0.290	+0.032	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042278 vs MFSD10 — HNSC

Explore this scatter interactively →