Purine nucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DGUOK, ICMT, and ADA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DGUOK grouped by Purine nucleoside metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DGUOK →	-0.242	-1.092	.005	.003	2	8
CNS	ICMT →	-0.190	-0.813	<.001	<.001	3	6
BLOOD_Leukemia	ADA →	-0.328	-1.471	.002	.003	3	5
STOMACH	ODR4 →	-0.214	-1.912	.005	<.001	3	5
STOMACH	MTAP →	-0.228	-1.842	.007	<.001	3	5
SOFT_TISSUE	CCT6A →	-0.269	-1.552	.007	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DGUOK by Purine nucleoside metabolic process activity — OVARY

Explore this box plot interactively →